{"id":180,"date":"2025-03-27T20:24:41","date_gmt":"2025-03-27T20:24:41","guid":{"rendered":"https:\/\/www.dr-cee.net\/?page_id=180"},"modified":"2025-04-14T07:12:42","modified_gmt":"2025-04-14T07:12:42","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.dr-cee.net\/?page_id=180","title":{"rendered":"Publications"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Manuscripts in Preparation<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>How can cancer risk communication result in protection motivation and behaviour change?<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong>, W.A.P. Klein and J. Usher-Smith.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Intended Journal: J. of Behavioural Medicine<\/p>\n\n\n\n<div style=\"height:104px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Peer-reviewed Publications<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Analysis of the components of cancer risk perception and links with intention and behaviour: A UK-based study<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong>, J. Campbell, W.M.P. Klein, R.A. Ferrer and J.A. Usher-Smith<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">PLoS One, 2022 Jan 13; 17(1):e0262197. DOI: 10.1371\/journal.pone.0262197<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Structure-based design of potent and orally active isoindolinone inhibitors of the MDM2-p53 protein-protein interaction<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">G. Chessari, I.R. Hardcastle, J.S. Ahn, B. Anil, E. Anscombe, R.H. Bahn, L.D. Bevan, T.J. Blackburn, I.Buck, C. Cano, B. Carbain, J. Castro, B. Cons, S.J. Cully, J.A. Endicott, L. Fazal, B.T. Golding, R.J. Griffin, K. Haggerty, S.J. Harnor, K.Hearn, S. Hobson, R.S. Holvey, S. Howard, C.E. Jennings, C.N. Johnson, J. Lunec, D.C. Miller, D.R. Newell, M.E.M. Noble, Judith Reeks, C.H. Revill, <strong>C. Riedinger<\/strong>, J.D. St. Denis, E. Tamanini, H. Thomas, N.TN. Thompson, M.Vinkovic, S.R. Wedge, P.A. Williams, N.E. Wilsher, B. Zhang and Y. Zhao.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">J. Med. Chem., 2021; 64: 4071-4088. <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c02188\">DOI: 10.1021\/acs.jmedchem.0c02188<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The Impact of Information about Different Absolute Benefits and Harms on Intention to Participate in Colorectal Cancer Screening: A Think-aloud Study and Online Randomised Experiment. <\/em><em><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">J.A. Usher-Smith, K.M. Mills, <strong>C. Riedinger<\/strong>, C. L. Saunders, L.M. Helsingen, L. Lytvyn, M. Buskermolen, I. Lansdorp-Vogelaar, M. Bretthauer, G. Guyatt and S.J. Griffin. PLoS One, 2021, 16(2):e0246991. DOI: 10.1371\/journal.pone.0246991<em><\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>The structure of an MDM2\/Nutlin-3a complex, solved by use of a validated MDM2 surface entropy reduction mutant.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B. Anil, <strong>C. Riedinger<\/strong>, J. A. Endicott and M. E. Noble. Acta Crystallogr. D, 2013, 69(Pt 8):1358-66. DOI: 10.1107\/S0907444913004459DOI: 10.1042\/BJ20120542<em><\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Structural and functional characterisation of Rpn12 identifies residues required for Rpn10 proteasome incorporation.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong>, J. Boehringer, K. Paraskevopoulos, E.D. Lowe, C. Khoudian, D. Smith, M.E. Noble and J. A. Endicott. Biochem. J., 2012, 448 (1) DOI: 10.1042\/BJ20120542<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>MDM2-p53 protein-protein interaction inhibitors: A-ring substituted isoindolinones.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Watson, J. Liu, K. Bennaceur, C. Drummond, J. A. Endicott,B. T. Golding, R. J. Griffin, K. Haggerty, X. Lu,&nbsp; J. M. McDonnell, D. R. Newell, M. E. Noble, C. H. Revill , <strong>C. Riedinger<\/strong>, Q. Xu, Y. Zhao,&nbsp; J. Lunec<sup>, <\/sup>and I. R. Hardcastle. Bioorg. Med. Chem. Lett., 2011, 21 (19) DOI: 10.1016\/j.bmcl.2011.07.084<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">R. Hardcastle, J. Lui, A. Watson, S.U. Ahmed, T.J. Blackburn, K. Bennaceur, W. Clegg, C. Drummond, J.A. Endicott, B.T. Golding, R.J. Griffin, J. Gruber, K. Haggerty, R.W. Harrington, C. Hutton, S. Kemp, J.M. McDonnell, D.R. Newell, M.E. Noble, S.L. Payne, C.H. Revill, <strong>C. Riedinger<\/strong>, Q. Xu, J. Lunec. J. Med. Chem., 2011, 54 (5). DOI: 10.1021\/jm1011929<em><\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Understanding Small-Molecule Binding to MDM2: Insights to Structural Effects of Isoindolinone Inhibitors from NMR<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C.Riedinger<\/strong>, M.E. Noble, D.J. Wright, F. Mulks, I.R. Hardcastle, J.A. Endicott and J.M. McDonnell<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Chem. Biol. Drug Design, 2011, 77 (5). DOI: 10.1111\/j.1747-0285.2011.01091.x<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong>, J. B\u00f6hringer, J.-F. Trempe, E. Lowe, N.R. Brown, K. Gehring, M. E. M. Noble, C. Gordon and J. A. Endicott. J. Biol. Chem., 2010, 285 (44). DOI: 10.1074\/jbc.M110.134510<em><\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Inhibitors of MDM2 and MDMX: a structural perspective.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong> and J.M. McDonnell. Future Medicinal Chemistry, 2009, 1 (6). DOI: 10.4155\/fmc.09.75<em><\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>All change: protein conformation and the ubiquitination reaction cascade.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong> and J.A. Endicott. F1000 Biology Reports, 2009, 19 (1). DOI: 10.3410:B1-19<em><\/em><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>C. Riedinger<\/strong>, J.A. Endicott, S.J. Kemp, L.A. Smyth, A. Watson, E. Valeur, B.T. Golding, R.J.Griffin, I.R. Hardcastle, M.E. Noble and J.M. McDonnell. J. Am. Chem. Soc., 2008, 130 (47) DOI: 10.1021\/ja8062088<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Patents<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>New therapeutic targets: Isoindolinone inhibitors of MDM2\/p53<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">B.T. Golding, <strong>C. Riedinger<\/strong>, I.R. Hardcastle, E. Valeur, A.F. Watson, M. Noble<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Patent Number: GB0811643.6, Applicant: Cancer Research Technology Limited<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Date filed: 25 June 2008, date published: 25 December 2009 \u2013 note: this patent has also been filed in the US<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Manuscripts in Preparation How can cancer risk communication result in protection motivation and behaviour change? C. Riedinger, W.A.P. Klein and J. Usher-Smith. Intended Journal: J. of Behavioural Medicine Peer-reviewed Publications Analysis of the components of cancer risk perception and links with intention and behaviour: A UK-based study C. Riedinger, J. Campbell, W.M.P. Klein, R.A. Ferrer &hellip; <a href=\"https:\/\/www.dr-cee.net\/?page_id=180\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-180","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=\/wp\/v2\/pages\/180","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=180"}],"version-history":[{"count":7,"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=\/wp\/v2\/pages\/180\/revisions"}],"predecessor-version":[{"id":204,"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=\/wp\/v2\/pages\/180\/revisions\/204"}],"wp:attachment":[{"href":"https:\/\/www.dr-cee.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}