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  • The Structure of an MDM2-Nutlin-3a Complex Solved by the Use of a Validated MDM2 Surface-entropy Reduction Mutant  
    B. Anil, C. Riedinger, J.A. Endicott and M.E. Noble
    Acta Crystallogr D Biol Crystallogr, 2013 Aug; 69(Pt 8):1358-66
  • Structural and Functional Characterisation of Rpn12 Identifies Residues Required for Rpn10 Proteasome Incorporation
    C. Riedinger*, J. Boehringer*, K. Paraskevopoulos, E.O.D. Johnson, C. Khoudian, D. Smith, M.E.M. Noble, C. Gordon & J.A. Endicott
    Biochem Journal, 2012. DOI: 10.1042/BJ20120542
  • MDM2-p53 Protein-protein Interaction Inhibitors: A-ring Substituted Isoindolinones
    A. Watson, J. Liu, K. Bennaceur, C. Drummond, J. A. Endicott, B. T. Golding, R. J. Griffin, K. Haggerty, X. Lu, J. M. McDonnell, D. R. Newell, M. E. Noble, C. H. Revill , C. Riedinger, Q. Xu, Y. Zhao, J. Lunec, and I. R. Hardcastle
    Bioorg. & Med. Chem. Letters, 2011 Oct1; 21(19):5916-9
  • Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency
    R. Hardcastle, J. Lui, A. Watson, S.U. Ahmed, T.J. Blackburn, K. Bennaceur, W. Clegg, C. Drummond, J.A. Endicott, B.T. Golding, R.J. Griffin, J. Gruber, K. Haggerty, R.W. Harrington, C. Hutton, S. Kemp, J.M. McDonnell, D.R. Newell, M.E. Noble, S.L. Payne, C.H. Revill, C. Riedinger, Q. Xu, J. Lunec
    J. Med. Chem., 2011, 54 (5)
  • Understanding Small-Molecule Binding to MDM2: Insights to Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy
    C. Riedinger, M.E. Noble, D.J. Wright, F. Mulks, I.R. Hardcastle, J.A. Endicott and J.M. McDonnell
    Chem. Biol. Drug Design, 2011 May; 77(5):301-8. DOI: 10.1111/j.1747-0285.2011.01091.x
  • Structure of Rpn10 and its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
    C. Riedinger, J. Böhringer, J.-F. Trempe, E. Lowe, N.R. Brown, K. Gehring, M. E. M. Noble, C. Gordon and J. A. Endicott
    J. Biol. Chem., 2010, 285 (44)
  • Inhibitors of MDM2 and MDMX: a Structural Perspective
    C. Riedinger and J.M. McDonnell
    Future Medicinal Chemistry, 2009, 1 (6)
  • All Change: Protein Conformation and the Ubiquitination Reaction Cascade
    C. Riedinger and J.A. Endicott
    F1000 Biology Reports, 2009, 19 (1)
  • Analysis of Chemical Shift Changes Reveals the Binding Modes of Isoindolinone Inhibitors of the MDM2-p53 Interaction
    C. Riedinger, J.A. Endicott, S.J. Kemp, L.A. Smyth, A. Watson, E. Valeur, B.T. Golding, R.J.Griffin, I.R. Hardcastle, M.E. Noble and J.M. McDonnell
    J. Am. Chem. Soc., 2008, 130 (47)


  • New therapeutic targets: Isoindolinone inhibitors of MDM2/p53
    B.T. Golding, C. Riedinger, I.R. Hardcastle, E. Valeur, A.F. Watson, M. Noble
    Patent Number: GB0811643.6, Applicant: Cancer Research Technology Limited
    Date filed: 25 June 2008, date published: 25 December 2009


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